The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes
The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Antigen-bearing dendritic cells transit through the lymphatics via chemokine receptor CCR7–dependent chemotactic cues. Rot and colleagues show that the atypical chemokine receptor CCRL1 establishes chemokine polarity in the subscapsular sinus that enables entry into the lymph node.
Afferent lymph–borne dendritic cells essentially rely on the che...
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Full title
The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes
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TN_cdi_swepub_primary_oai_DiVA_org_uu_288515
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_288515
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ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/ni.2889
