Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsola...
Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Molecular changes in cortical areas of addicted brain may underlie cognitive impairment and loss of control over intake of addictive substances and alcohol. Prodynorphin (PDYN) gives rise to dynorphin (DYNs) opioid peptides which target kappa-opioid receptor (KOR). DYNs mediate alcohol-induced impairment of learning and memory, while KOR antagonist...
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Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics
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TN_cdi_swepub_primary_oai_DiVA_org_uu_358683
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_358683
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ISSN
2158-3188
E-ISSN
2158-3188
DOI
10.1038/s41398-017-0075-5
