Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
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Author / Creator
Brem, Jürgen , Panduwawala, Tharindi , Hansen, Jon Ulf , Hewitt, Joanne , Liepins, Edgars , Donets, Pawel , Espina, Laura , Farley, Alistair J. M. , Shubin, Kirill , Campillos, Gonzalo Gomez , Kiuru, Paula , Shishodia, Shifali , Krahn, Daniel , Leśniak, Robert K. , Schmidt (Adrian), Juliane , Calvopiña, Karina , Turrientes, María-Carmen , Kavanagh, Madeline E. , Lubriks, Dmitrijs , Hinchliffe, Philip , Langley, Gareth W. , Aboklaish, Ali F. , Eneroth, Anders , Backlund, Maria , Baran, Andrei G. , Nielsen, Elisabet I. , Speake, Michael , Kuka, Janis , Robinson, John , Grinberga, Solveiga , Robinson, Lindsay , McDonough, Michael A. , Rydzik, Anna M. , Leissing, Thomas M. , Jimenez-Castellanos, Juan Carlos , Avison, Matthew B. , Da Silva Pinto, Solange , Pannifer, Andrew D. , Martjuga, Marina , Widlake, Emma , Priede, Martins , Hopkins Navratilova, Iva , Gniadkowski, Marek , Belfrage, Anna Karin , Brandt, Peter , Yli-Kauhaluoma, Jari , Bacque, Eric , Page, Malcolm G. P. , Björkling, Fredrik , Tyrrell, Jonathan M. , Spencer, James , Lang, Pauline A. , Baranczewski, Pawel , Cantón, Rafael , McElroy, Stuart P. , Jones, Philip S. , Baquero, Fernando , Suna, Edgars , Morrison, Angus , Walsh, Timothy R. and Schofield, Christopher J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-β-lactamases (MBLs). Here we report the discovery and optimization of potent broad-spectrum MBL inhibitors. A high-throughput screen for NDM-1 inhibitors identified indole-2-carboxylates (InCs) as potential β-lactamase stable β-lactam mimics. Subsequent str...
Alternative Titles
Full title
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Authors, Artists and Contributors
Author / Creator
Panduwawala, Tharindi
Hansen, Jon Ulf
Hewitt, Joanne
Liepins, Edgars
Donets, Pawel
Espina, Laura
Farley, Alistair J. M.
Shubin, Kirill
Campillos, Gonzalo Gomez
Kiuru, Paula
Shishodia, Shifali
Krahn, Daniel
Leśniak, Robert K.
Schmidt (Adrian), Juliane
Calvopiña, Karina
Turrientes, María-Carmen
Kavanagh, Madeline E.
Lubriks, Dmitrijs
Hinchliffe, Philip
Langley, Gareth W.
Aboklaish, Ali F.
Eneroth, Anders
Backlund, Maria
Baran, Andrei G.
Nielsen, Elisabet I.
Speake, Michael
Kuka, Janis
Robinson, John
Grinberga, Solveiga
Robinson, Lindsay
McDonough, Michael A.
Rydzik, Anna M.
Leissing, Thomas M.
Jimenez-Castellanos, Juan Carlos
Avison, Matthew B.
Da Silva Pinto, Solange
Pannifer, Andrew D.
Martjuga, Marina
Widlake, Emma
Priede, Martins
Hopkins Navratilova, Iva
Gniadkowski, Marek
Belfrage, Anna Karin
Brandt, Peter
Yli-Kauhaluoma, Jari
Bacque, Eric
Page, Malcolm G. P.
Björkling, Fredrik
Tyrrell, Jonathan M.
Spencer, James
Lang, Pauline A.
Baranczewski, Pawel
Cantón, Rafael
McElroy, Stuart P.
Jones, Philip S.
Baquero, Fernando
Suna, Edgars
Morrison, Angus
Walsh, Timothy R.
Schofield, Christopher J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_uu_465165
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_465165
Other Identifiers
ISSN
1755-4330,1755-4349
E-ISSN
1755-4349
DOI
10.1038/s41557-021-00831-x
