A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derive...
A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
About this item
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Author / Creator
Tay, Apple Hui Min , Prieto-Díaz, Rubén , Neo, Shiyong , Tong, Le , Chen, Xinsong , Carannante, Valentina , Önfelt, Björn , Hartman, Johan , Haglund, Felix , Majellaro, Maria , Azuaje, Jhonny , Garcia-Mera, Xerardo , Brea, Jose M , Loza, Maria I , Jespers, Willem , Gutierrez-de-Teran, Hugo , Sotelo, Eddy and Lundqvist, Andreas
Publisher
England
Journal title
Language
English
Formats
Publication information
Publisher
England
Subjects
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Scope and Contents
Contents
Adenosine is a metabolite that suppresses antitumor immune response of T and NK cells via extracellular binding to the two subtypes of adenosine-2 receptors, A
ARs. While blockade of the A
ARs subtype effectively rescues lymphocyte activity, with four A
AR antagonists currently in anticancer clinical trials, less is known for the therapeut...
Alternative Titles
Full title
A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_uu_475600
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_475600
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2022-004592
