GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
About this item
Full title
Author / Creator
Shigeto, Makoto , Ramracheya, Reshma , Tarasov, Andrei I. , Cha, Chae Young , Chibalina, Margarita V. , Hastoy, Benoit , Philippaert, Koenraad , Reinbothe, Thomas , Rorsman, Nils , Salehi, Albert , Sones, William R. , Vergari, Elisa , Weston, Cathryn , Gorelik, Julia , Katsura, Masashi , Nikolaev, Viacheslav O. , Vennekens, Rudi , Zaccolo, Manuela , Galione, Antony , Johnson, Paul R.V. , Kaku, Kohei , Ladds, Graham and Rorsman, Patrik
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretion in pancreatic islets. Here, we examined the mechanisms by which GLP-1 stimulates insulin secretion...
Alternative Titles
Full title
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
Authors, Artists and Contributors
Author / Creator
Ramracheya, Reshma
Tarasov, Andrei I.
Cha, Chae Young
Chibalina, Margarita V.
Hastoy, Benoit
Philippaert, Koenraad
Reinbothe, Thomas
Rorsman, Nils
Salehi, Albert
Sones, William R.
Vergari, Elisa
Weston, Cathryn
Gorelik, Julia
Katsura, Masashi
Nikolaev, Viacheslav O.
Vennekens, Rudi
Zaccolo, Manuela
Galione, Antony
Johnson, Paul R.V.
Kaku, Kohei
Ladds, Graham
Rorsman, Patrik
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_229691
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_229691
Other Identifiers
ISSN
0021-9738,1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI81975
