Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The structure of yeast Hrd1 in complex with Hrd3 shows that Hrd1 forms an aqueous cavity with a lateral seal within the endoplasmic reticulum membrane, shedding light on how misfolded proteins are transported out of the endoplasmic reticulum.
A conduit to protein degradation
Endoplasmic reticulum-associated protein degradation (ERAD) is an im...
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Full title
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
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TN_cdi_swepub_primary_oai_gup_ub_gu_se_257813
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_257813
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature23314
