An atlas of genetic influences on osteoporosis in humans and mice
An atlas of genetic influences on osteoporosis in humans and mice
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Author / Creator
23andMe Research Team , Morris, John A. , Kemp, John P. , Youlten, Scott E. , Laurent, Laetitia , Logan, John G. , Chai, Ryan C. , Vulpescu, Nicholas A. , Forgetta, Vincenzo , Kleinman, Aaron , Mohanty, Sindhu T. , Sergio, C. Marcelo , Quinn, Julian , Nguyen-Yamamoto, Loan , Luco, Aimee-Lee , Vijay, Jinchu , Simon, Marie-Michelle , Pramatarova, Albena , Medina-Gomez, Carolina , Trajanoska, Katerina , Ghirardello, Elena J. , Butterfield, Natalie C. , Curry, Katharine F. , Leitch, Victoria D. , Sparkes, Penny C. , Adoum, Anne-Tounsia , Mannan, Naila S. , Komla-Ebri, Davide S. K. , Pollard, Andrea S. , Dewhurst, Hannah F. , Hassall, Thomas A. D. , Beltejar, Michael-John G. , Adams, Douglas J. , Vaillancourt, Suzanne M. , Kaptoge, Stephen , Baldock, Paul , Cooper, Cyrus , Reeve, Jonathan , Ntzani, Evangelia E. , Evangelou, Evangelos , Ohlsson, Claes , Karasik, David , Rivadeneira, Fernando , Kiel, Douglas P. , Tobias, Jonathan H. , Gregson, Celia L. , Harvey, Nicholas C. , Grundberg, Elin , Goltzman, David , Adams, David J. , Lelliott, Christopher J. , Hinds, David A. , Ackert-Bicknell, Cheryl L. , Hsu, Yi-Hsiang , Maurano, Matthew T. , Croucher, Peter I. , Williams, Graham R. , Bassett, J. H. Duncan , Evans, David M. and Richards, J. Brent
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associate...
Alternative Titles
Full title
An atlas of genetic influences on osteoporosis in humans and mice
Authors, Artists and Contributors
Author / Creator
Morris, John A.
Kemp, John P.
Youlten, Scott E.
Laurent, Laetitia
Logan, John G.
Chai, Ryan C.
Vulpescu, Nicholas A.
Forgetta, Vincenzo
Kleinman, Aaron
Mohanty, Sindhu T.
Sergio, C. Marcelo
Quinn, Julian
Nguyen-Yamamoto, Loan
Luco, Aimee-Lee
Vijay, Jinchu
Simon, Marie-Michelle
Pramatarova, Albena
Medina-Gomez, Carolina
Trajanoska, Katerina
Ghirardello, Elena J.
Butterfield, Natalie C.
Curry, Katharine F.
Leitch, Victoria D.
Sparkes, Penny C.
Adoum, Anne-Tounsia
Mannan, Naila S.
Komla-Ebri, Davide S. K.
Pollard, Andrea S.
Dewhurst, Hannah F.
Hassall, Thomas A. D.
Beltejar, Michael-John G.
Adams, Douglas J.
Vaillancourt, Suzanne M.
Kaptoge, Stephen
Baldock, Paul
Cooper, Cyrus
Reeve, Jonathan
Ntzani, Evangelia E.
Evangelou, Evangelos
Ohlsson, Claes
Karasik, David
Rivadeneira, Fernando
Kiel, Douglas P.
Tobias, Jonathan H.
Gregson, Celia L.
Harvey, Nicholas C.
Grundberg, Elin
Goltzman, David
Adams, David J.
Lelliott, Christopher J.
Hinds, David A.
Ackert-Bicknell, Cheryl L.
Hsu, Yi-Hsiang
Maurano, Matthew T.
Croucher, Peter I.
Williams, Graham R.
Bassett, J. H. Duncan
Evans, David M.
Richards, J. Brent
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_276254
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_276254
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0302-x
