Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene d...
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain
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Author / Creator
LonDownS Consortium , Alić, Ivan , Goh, Pollyanna A. , Murray, Aoife , Portelius, Erik , Gkanatsiou, Eleni , Gough, Gillian , Mok, Kin Y. , Koschut, David , Brunmeir, Reinhard , Yeap, Yee Jie , O’Brien, Niamh L. , Groet, Jürgen , Shao, Xiaowei , Havlicek, Steven , Dunn, N. Ray , Kvartsberg, Hlin , Brinkmalm, Gunnar , Hithersay, Rosalyn , Startin, Carla , Hamburg, Sarah , Phillips, Margaret , Pervushin, Konstantin , Turmaine, Mark , Wallon, David , Rovelet-Lecrux, Anne , Soininen, Hilkka , Volpi, Emanuela , Martin, Joanne E. , Foo, Jia Nee , Becker, David L. , Rostagno, Agueda , Ghiso, Jorge , Krsnik, Željka , Šimić, Goran , Kostović, Ivica , Mitrečić, Dinko , Francis, Paul T. , Blennow, Kaj , Strydom, Andre , Hardy, John , Zetterberg, Henrik and Nižetić, Dean
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A population of more than six million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)-precursor-protein gene. We report AD-like pathology in cerebral organoids grown in vitro from non-invas...
Alternative Titles
Full title
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain
Authors, Artists and Contributors
Author / Creator
Alić, Ivan
Goh, Pollyanna A.
Murray, Aoife
Portelius, Erik
Gkanatsiou, Eleni
Gough, Gillian
Mok, Kin Y.
Koschut, David
Brunmeir, Reinhard
Yeap, Yee Jie
O’Brien, Niamh L.
Groet, Jürgen
Shao, Xiaowei
Havlicek, Steven
Dunn, N. Ray
Kvartsberg, Hlin
Brinkmalm, Gunnar
Hithersay, Rosalyn
Startin, Carla
Hamburg, Sarah
Phillips, Margaret
Pervushin, Konstantin
Turmaine, Mark
Wallon, David
Rovelet-Lecrux, Anne
Soininen, Hilkka
Volpi, Emanuela
Martin, Joanne E.
Foo, Jia Nee
Becker, David L.
Rostagno, Agueda
Ghiso, Jorge
Krsnik, Željka
Šimić, Goran
Kostović, Ivica
Mitrečić, Dinko
Francis, Paul T.
Blennow, Kaj
Strydom, Andre
Hardy, John
Zetterberg, Henrik
Nižetić, Dean
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_295015
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_295015
Other Identifiers
ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-020-0806-5
