Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap...
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
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Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators , China Kadoorie Biobank Collaborative Group , The ICAN Study Group , BioBank Japan Project Consortium , HUNT All-In Stroke , International Stroke Genetics Consortium (ISGC) , CADISP Group , ICAN Study Group , Bakker, Mark K. , van der Spek, Rick A. A. , van Rheenen, Wouter , Morel, Sandrine , Bourcier, Romain , Hostettler, Isabel C. , Alg, Varinder S. , van Eijk, Kristel R. , Koido, Masaru , Akiyama, Masato , Terao, Chikashi , Matsuda, Koichi , Walters, Robin G. , Lin, Kuang , Li, Liming , Millwood, Iona Y. , Chen, Zhengming , Rouleau, Guy A. , Zhou, Sirui , Rannikmäe, Kristiina , Sudlow, Cathie L. M. , Houlden, Henry , van den Berg, Leonard H. , Dina, Christian , Naggara, Olivier , Gentric, Jean-Christophe , Shotar, Eimad , Eugène, François , Desal, Hubert , Winsvold, Bendik S. , Børte, Sigrid , Johnsen, Marianne Bakke , Brumpton, Ben M. , Sandvei, Marie Søfteland , Willer, Cristen J. , Hveem, Kristian , Zwart, John-Anker , Verschuren, W. M. Monique , Friedrich, Christoph M. , Hirsch, Sven , Schilling, Sabine , Dauvillier, Jérôme , Martin, Olivier , Jones, Gregory T. , Bown, Matthew J. , Ko, Nerissa U. , Kim, Helen , Coleman, Jonathan R. I. , Breen, Gerome , Zaroff, Jonathan G. , Klijn, Catharina J. M. , Malik, Rainer , Dichgans, Martin , Sargurupremraj, Muralidharan , Tatlisumak, Turgut , Amouyel, Philippe , Debette, Stéphanie , Rinkel, Gabriel J. E. , Worrall, Bradford B. , Pera, Joanna , Slowik, Agnieszka , Gaál-Paavola, Emília I. , Niemelä, Mika , Jääskeläinen, Juha E. , von Und Zu Fraunberg, Mikael , Lindgren, Antti , Broderick, Joseph P. , Werring, David J. , Woo, Daniel , Redon, Richard , Bijlenga, Philippe , Kamatani, Yoichiro , Veldink, Jan H. and Ruigrok, Ynte M.
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of whic...
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Full title
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Authors, Artists and Contributors
Author / Creator
China Kadoorie Biobank Collaborative Group
The ICAN Study Group
BioBank Japan Project Consortium
HUNT All-In Stroke
International Stroke Genetics Consortium (ISGC)
CADISP Group
ICAN Study Group
Bakker, Mark K.
van der Spek, Rick A. A.
van Rheenen, Wouter
Morel, Sandrine
Bourcier, Romain
Hostettler, Isabel C.
Alg, Varinder S.
van Eijk, Kristel R.
Koido, Masaru
Akiyama, Masato
Terao, Chikashi
Matsuda, Koichi
Walters, Robin G.
Lin, Kuang
Li, Liming
Millwood, Iona Y.
Chen, Zhengming
Rouleau, Guy A.
Zhou, Sirui
Rannikmäe, Kristiina
Sudlow, Cathie L. M.
Houlden, Henry
van den Berg, Leonard H.
Dina, Christian
Naggara, Olivier
Gentric, Jean-Christophe
Shotar, Eimad
Eugène, François
Desal, Hubert
Winsvold, Bendik S.
Børte, Sigrid
Johnsen, Marianne Bakke
Brumpton, Ben M.
Sandvei, Marie Søfteland
Willer, Cristen J.
Hveem, Kristian
Zwart, John-Anker
Verschuren, W. M. Monique
Friedrich, Christoph M.
Hirsch, Sven
Schilling, Sabine
Dauvillier, Jérôme
Martin, Olivier
Jones, Gregory T.
Bown, Matthew J.
Ko, Nerissa U.
Kim, Helen
Coleman, Jonathan R. I.
Breen, Gerome
Zaroff, Jonathan G.
Klijn, Catharina J. M.
Malik, Rainer
Dichgans, Martin
Sargurupremraj, Muralidharan
Tatlisumak, Turgut
Amouyel, Philippe
Debette, Stéphanie
Rinkel, Gabriel J. E.
Worrall, Bradford B.
Pera, Joanna
Slowik, Agnieszka
Gaál-Paavola, Emília I.
Niemelä, Mika
Jääskeläinen, Juha E.
von Und Zu Fraunberg, Mikael
Lindgren, Antti
Broderick, Joseph P.
Werring, David J.
Woo, Daniel
Redon, Richard
Bijlenga, Philippe
Kamatani, Yoichiro
Veldink, Jan H.
Ruigrok, Ynte M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_300001
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_300001
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-020-00725-7
