Pericyte phenotype switching alleviates immunosuppression and sensitizes vascularized tumors to immu...
Pericyte phenotype switching alleviates immunosuppression and sensitizes vascularized tumors to immunotherapy in preclinical models
About this item
Full title
Author / Creator
Li, Zhi-Jie , He, Bo , Domenichini, Alice , Satiaputra, Jiulia , Wood, Kira H. , Lakhiani, Devina D. , Bashaw, Abate A. , Nilsson, Lisa M. , Li, Ji , Bastow, Edward R. , Johansson-Percival, Anna , Denisenko, Elena , Forrest, Alistair R.R. , Sakaram, Suraj , Carretero, Rafael , Hämmerling, Günter J. , Nilsson, Jonas A. , Lee, Gabriel Y.F. and Ganss, Ruth
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
T cell-based immunotherapies are a promising therapeutic approach for multiple malignancies, but their efficacy is limited by tumor hypoxia arising from dysfunctional blood vessels. Here, we report that cell-intrinsic properties of a single vascular component, namely the pericyte, contribute to the control of tumor oxygenation, macrophage polarizat...
Alternative Titles
Full title
Pericyte phenotype switching alleviates immunosuppression and sensitizes vascularized tumors to immunotherapy in preclinical models
Authors, Artists and Contributors
Author / Creator
He, Bo
Domenichini, Alice
Satiaputra, Jiulia
Wood, Kira H.
Lakhiani, Devina D.
Bashaw, Abate A.
Nilsson, Lisa M.
Li, Ji
Bastow, Edward R.
Johansson-Percival, Anna
Denisenko, Elena
Forrest, Alistair R.R.
Sakaram, Suraj
Carretero, Rafael
Hämmerling, Günter J.
Nilsson, Jonas A.
Lee, Gabriel Y.F.
Ganss, Ruth
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_346057
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_346057
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI179860
