Requirement of JNK2 for Scavenger Receptor A: Mediated Foam Cell Formation in Atherogenesis
Requirement of JNK2 for Scavenger Receptor A: Mediated Foam Cell Formation in Atherogenesis
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Author / Creator
Ricci, Romeo , Sumara, Grzegorz , Sumara, Izabela , Rozenberg, Izabela , Kurrer, Michael , Akhmedov, Alexander , Hersberger, Martin , Eriksson, Urs , Eberli, Franz R. , Becher, Burkhard , Borén, Jan , Chen, Mian , Cybulsky, Myron I. , Moore, Kathryn J. , Freeman, Mason W. , Wagner, Erwin F. , Matter, Christian M. and Lüscher, Thomas F.
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
In vitro studies suggest a role for c-Jun N-terminal kinases (JNKs) in proatherogenic cellular processes. We show that atherosclerosis-prone ApoE-/-mice simultaneously lacking JNK2 ($ApoE^{-/-} JNK2^{-/-}$mice), but not ApoE-/-
$JNK1^{-/-}$mice, developed less atherosclerosis than do ApoE-/-mice. Pharmacological inhibition of JNK activity effici...
Alternative Titles
Full title
Requirement of JNK2 for Scavenger Receptor A: Mediated Foam Cell Formation in Atherogenesis
Authors, Artists and Contributors
Author / Creator
Sumara, Grzegorz
Sumara, Izabela
Rozenberg, Izabela
Kurrer, Michael
Akhmedov, Alexander
Hersberger, Martin
Eriksson, Urs
Eberli, Franz R.
Becher, Burkhard
Borén, Jan
Chen, Mian
Cybulsky, Myron I.
Moore, Kathryn J.
Freeman, Mason W.
Wagner, Erwin F.
Matter, Christian M.
Lüscher, Thomas F.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_50312
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_50312
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.1101909
