Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and...
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
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Author / Creator
Zhao, Jing Hua , Stacey, David , Eriksson, Niclas , Macdonald-Dunlop, Erin , Hedman, Åsa K. , Kalnapenkis, Anette , Enroth, Stefan , Cozzetto, Domenico , Digby-Bell, Jonathan , Marten, Jonathan , Folkersen, Lasse , Herder, Christian , Jonsson, Lina , Bergen, Sarah E. , Gieger, Christian , Needham, Elise J. , Surendran, Praveen , Paul, Dirk S. , Polasek, Ozren , Thorand, Barbara , Grallert, Harald , Roden, Michael , Võsa, Urmo , Esko, Tonu , Hayward, Caroline , Johansson, Åsa , Gyllensten, Ulf , Powell, Nick , Hansson, Oskar , Mattsson-Carlgren, Niklas , Joshi, Peter K. , Danesh, John , Padyukov, Leonid , Klareskog, Lars , Landén, Mikael , Wilson, James F. , Siegbahn, Agneta , Wallentin, Lars , Mälarstig, Anders , Butterworth, Adam S. , Peters, James E. , Estonian Biobank Research Team , Strategiska forskningsområden (SFO) , LU profilområde: Proaktivt åldrande , Clinical Memory Research , Strategic research areas (SRA) , Neurology, Lund , Department of Clinical Sciences, Lund , Lund University Profile areas , Lund University , LU Profile Area: Proactive Ageing , Profile areas and other strong research environments , WCMM- Wallenberg center för molekylär medicinsk forskning , Department of Clinical Sciences, Malmö , Faculty of Medicine , Medicinska fakulteten , WCMM-Wallenberg Centre for Molecular Medicine , Institutionen för kliniska vetenskaper, Malmö , Institutionen för kliniska vetenskaper, Lund , Lunds universitet , Brain Injury After Cardiac Arrest , Lunds universitets profilområden , Klinisk minnesforskning , Profilområden och andra starka forskningsmiljöer , Sektion IV , Section IV , MultiPark: Multidisciplinary research focused on Parkinson´s disease and Neurologi, Lund
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59
c...
Alternative Titles
Full title
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
Authors, Artists and Contributors
Author / Creator
Stacey, David
Eriksson, Niclas
Macdonald-Dunlop, Erin
Hedman, Åsa K.
Kalnapenkis, Anette
Enroth, Stefan
Cozzetto, Domenico
Digby-Bell, Jonathan
Marten, Jonathan
Folkersen, Lasse
Herder, Christian
Jonsson, Lina
Bergen, Sarah E.
Gieger, Christian
Needham, Elise J.
Surendran, Praveen
Paul, Dirk S.
Polasek, Ozren
Thorand, Barbara
Grallert, Harald
Roden, Michael
Võsa, Urmo
Esko, Tonu
Hayward, Caroline
Johansson, Åsa
Gyllensten, Ulf
Powell, Nick
Hansson, Oskar
Mattsson-Carlgren, Niklas
Joshi, Peter K.
Danesh, John
Padyukov, Leonid
Klareskog, Lars
Landén, Mikael
Wilson, James F.
Siegbahn, Agneta
Wallentin, Lars
Mälarstig, Anders
Butterworth, Adam S.
Peters, James E.
Estonian Biobank Research Team
Strategiska forskningsområden (SFO)
LU profilområde: Proaktivt åldrande
Clinical Memory Research
Strategic research areas (SRA)
Neurology, Lund
Department of Clinical Sciences, Lund
Lund University Profile areas
Lund University
LU Profile Area: Proactive Ageing
Profile areas and other strong research environments
WCMM- Wallenberg center för molekylär medicinsk forskning
Department of Clinical Sciences, Malmö
Faculty of Medicine
Medicinska fakulteten
WCMM-Wallenberg Centre for Molecular Medicine
Institutionen för kliniska vetenskaper, Malmö
Institutionen för kliniska vetenskaper, Lund
Lunds universitet
Brain Injury After Cardiac Arrest
Lunds universitets profilområden
Klinisk minnesforskning
Profilområden och andra starka forskningsmiljöer
Sektion IV
Section IV
MultiPark: Multidisciplinary research focused on Parkinson´s disease
Neurologi, Lund
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_445114
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_445114
Other Identifiers
ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/s41590-023-01588-w
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