Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variants in ten genes confer substantial risk for schizophrenia
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Singh, Tarjinder , Poterba, Timothy , Curtis, David , Akil, Huda , Al Eissa, Mariam , Barchas, Jack D. , Bass, Nicholas , Bigdeli, Tim B. , Breen, Gerome , Bromet, Evelyn J. , Buckley, Peter F. , Bunney, William E. , Bybjerg-Grauholm, Jonas , Byerley, William F. , Chapman, Sinéad B. , Chen, Wei J. , Churchhouse, Claire , Craddock, Nicholas , DeLisi, Lynn , Dodge, Sheila , Escamilla, Michael A. , Eskelinen, Saana , Fanous, Ayman H. , Faraone, Stephen V. , Fiorentino, Alessia , Francioli, Laurent , Gabriel, Stacey B. , Gage, Diane , Gagliano Taliun, Sarah A. , Ganna, Andrea , Genovese, Giulio , Grove, Jakob , Hall, Mei-Hua , Heyne, Henrike O. , Holi, Matti , Hougaard, David M. , Howrigan, Daniel P. , Huang, Hailiang , Hwu, Hai-Gwo , Kahn, René S. , Kang, Hyun Min , Karczewski, Konrad J. , Knowles, James A. , Lee, Francis S. , Lehrer, Douglas S. , Lescai, Francesco , Marder, Stephen R. , McCarroll, Steven A. , McIntosh, Andrew M. , Milani, Lili , Morley, Christopher P. , Morris, Derek W. , Mortensen, Preben Bo , Nordentoft, Merete , O’Brien, Niamh L. , Olivares, Ana Maria , Ongur, Dost , Ouwehand, Willem H. , Palmer, Duncan S. , Paunio, Tiina , Quested, Digby , Rapaport, Mark H. , Rees, Elliott , Rollins, Brandi , Satterstrom, F. Kyle , Schatzberg, Alan , Scolnick, Edward , Scott, Laura J. , Sharp, Sally I. , Sklar, Pamela , Smoller, Jordan W. , Solomonson, Matthew , Stahl, Eli A. , Stevens, Christine R. , Suvisaari, Jaana , Watts, Nicholas A. , Blackwood, Douglas H. , Cohen, Bruce M. , Corvin, Aiden P. , Esko, Tõnu , Freimer, Nelson B. , Glatt, Stephen J. , Hultman, Christina M. , McQuillin, Andrew , Palotie, Aarno , Pato, Carlos N. , Pato, Michele T. , Pulver, Ann E. , St. Clair, David , Tsuang, Ming T. , Vawter, Marquis P. , Walters, James T. , Werge, Thomas M. , Ophoff, Roel A. , Sullivan, Patrick F. , Owen, Michael J. , Boehnke, Michael , O’Donovan, Michael C. , Neale, Benjamin M. and Daly, Mark J.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate ultra-rare coding variants (URVs) in 10 genes as conferring substantial risk for schizophrenia (odds ratios of 3–50,
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Alternative Titles
Full title
Rare coding variants in ten genes confer substantial risk for schizophrenia
Authors, Artists and Contributors
Author / Creator
Poterba, Timothy
Curtis, David
Akil, Huda
Al Eissa, Mariam
Barchas, Jack D.
Bass, Nicholas
Bigdeli, Tim B.
Breen, Gerome
Bromet, Evelyn J.
Buckley, Peter F.
Bunney, William E.
Bybjerg-Grauholm, Jonas
Byerley, William F.
Chapman, Sinéad B.
Chen, Wei J.
Churchhouse, Claire
Craddock, Nicholas
DeLisi, Lynn
Dodge, Sheila
Escamilla, Michael A.
Eskelinen, Saana
Fanous, Ayman H.
Faraone, Stephen V.
Fiorentino, Alessia
Francioli, Laurent
Gabriel, Stacey B.
Gage, Diane
Gagliano Taliun, Sarah A.
Ganna, Andrea
Genovese, Giulio
Grove, Jakob
Hall, Mei-Hua
Heyne, Henrike O.
Holi, Matti
Hougaard, David M.
Howrigan, Daniel P.
Huang, Hailiang
Hwu, Hai-Gwo
Kahn, René S.
Kang, Hyun Min
Karczewski, Konrad J.
Knowles, James A.
Lee, Francis S.
Lehrer, Douglas S.
Lescai, Francesco
Marder, Stephen R.
McCarroll, Steven A.
McIntosh, Andrew M.
Milani, Lili
Morley, Christopher P.
Morris, Derek W.
Mortensen, Preben Bo
Nordentoft, Merete
O’Brien, Niamh L.
Olivares, Ana Maria
Ongur, Dost
Ouwehand, Willem H.
Palmer, Duncan S.
Paunio, Tiina
Quested, Digby
Rapaport, Mark H.
Rees, Elliott
Rollins, Brandi
Satterstrom, F. Kyle
Schatzberg, Alan
Scolnick, Edward
Scott, Laura J.
Sharp, Sally I.
Sklar, Pamela
Smoller, Jordan W.
Solomonson, Matthew
Stahl, Eli A.
Stevens, Christine R.
Suvisaari, Jaana
Watts, Nicholas A.
Blackwood, Douglas H.
Cohen, Bruce M.
Corvin, Aiden P.
Esko, Tõnu
Freimer, Nelson B.
Glatt, Stephen J.
Hultman, Christina M.
McQuillin, Andrew
Palotie, Aarno
Pato, Carlos N.
Pato, Michele T.
Pulver, Ann E.
St. Clair, David
Tsuang, Ming T.
Vawter, Marquis P.
Walters, James T.
Werge, Thomas M.
Ophoff, Roel A.
Sullivan, Patrick F.
Owen, Michael J.
Boehnke, Michael
O’Donovan, Michael C.
Neale, Benjamin M.
Daly, Mark J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_454205
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_454205
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04556-w
