Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores tha...
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
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Author / Creator
Claringbould, Annique , Westra, Harm-Jan , Bonder, Marc Jan , Deelen, Patrick , Kirsten, Holger , Saha, Ashis , Yazar, Seyhan , Brugge, Harm , Oelen, Roy , de Vries, Dylan H. , van der Wijst, Monique G. P. , Kasela, Silva , Pervjakova, Natalia , Alves, Isabel , Favé, Marie-Julie , Agbessi, Mawussé , Christiansen, Mark W. , Jansen, Rick , Seppälä, Ilkka , Tong, Lin , Teumer, Alexander , Schramm, Katharina , Hemani, Gibran , Verlouw, Joost , Yaghootkar, Hanieh , Sönmez Flitman, Reyhan , Brown, Andrew , Kukushkina, Viktorija , Kalnapenkis, Anette , Rüeger, Sina , Porcu, Eleonora , Kettunen, Johannes , Lee, Bernett , Zhang, Futao , Qi, Ting , Arindrarto, Wibowo , Beutner, Frank , Dmitrieva, Julia , Elansary, Mahmoud , Fairfax, Benjamin P. , Georges, Michel , Heijmans, Bastiaan T. , Hewitt, Alex W. , Kähönen, Mika , Kim, Yungil , Knight, Julian C. , Kovacs, Peter , Krohn, Knut , Li, Shuang , Loeffler, Markus , Marigorta, Urko M. , Mei, Hailang , Momozawa, Yukihide , Müller-Nurasyid, Martina , Nauck, Matthias , Nivard, Michel G. , Penninx, Brenda W. J. H. , Pritchard, Jonathan K. , Raitakari, Olli T. , Rotzschke, Olaf , Slagboom, Eline P. , Stehouwer, Coen D. A. , Stumvoll, Michael , Sullivan, Patrick , ’t Hoen, Peter A. C. , Thiery, Joachim , Tönjes, Anke , van Dongen, Jenny , van Iterson, Maarten , Veldink, Jan H. , Völker, Uwe , Warmerdam, Robert , Wijmenga, Cisca , Swertz, Morris , Andiappan, Anand , Montgomery, Grant W. , Ripatti, Samuli , Perola, Markus , Kutalik, Zoltan , Dermitzakis, Emmanouil , Bergmann, Sven , van Meurs, Joyce , Prokisch, Holger , Ahsan, Habibul , Pierce, Brandon L. , Lehtimäki, Terho , Psaty, Bruce M. , Gharib, Sina A. , Awadalla, Philip , Milani, Lili , Ouwehand, Willem H. , Downes, Kate , Stegle, Oliver , Battle, Alexis , Visscher, Peter M. , Yang, Jian , Powell, Joseph , Gibson, Greg , Esko, Tõnu , Franke, Lude , i2QTL Consortium , BIOS Consortium , BIOS Consortium and i2QTL Consortium
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed
cis
- and
trans
-expression quantitative trait locus (eQTL) analyses using blood-derived expression from 31,684 individuals through the eQTLGen Consortium. We...
Alternative Titles
Full title
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Authors, Artists and Contributors
Author / Creator
Westra, Harm-Jan
Bonder, Marc Jan
Deelen, Patrick
Kirsten, Holger
Saha, Ashis
Yazar, Seyhan
Brugge, Harm
Oelen, Roy
de Vries, Dylan H.
van der Wijst, Monique G. P.
Kasela, Silva
Pervjakova, Natalia
Alves, Isabel
Favé, Marie-Julie
Agbessi, Mawussé
Christiansen, Mark W.
Jansen, Rick
Seppälä, Ilkka
Tong, Lin
Teumer, Alexander
Schramm, Katharina
Hemani, Gibran
Verlouw, Joost
Yaghootkar, Hanieh
Sönmez Flitman, Reyhan
Brown, Andrew
Kukushkina, Viktorija
Kalnapenkis, Anette
Rüeger, Sina
Porcu, Eleonora
Kettunen, Johannes
Lee, Bernett
Zhang, Futao
Qi, Ting
Arindrarto, Wibowo
Beutner, Frank
Dmitrieva, Julia
Elansary, Mahmoud
Fairfax, Benjamin P.
Georges, Michel
Heijmans, Bastiaan T.
Hewitt, Alex W.
Kähönen, Mika
Kim, Yungil
Knight, Julian C.
Kovacs, Peter
Krohn, Knut
Li, Shuang
Loeffler, Markus
Marigorta, Urko M.
Mei, Hailang
Momozawa, Yukihide
Müller-Nurasyid, Martina
Nauck, Matthias
Nivard, Michel G.
Penninx, Brenda W. J. H.
Pritchard, Jonathan K.
Raitakari, Olli T.
Rotzschke, Olaf
Slagboom, Eline P.
Stehouwer, Coen D. A.
Stumvoll, Michael
Sullivan, Patrick
’t Hoen, Peter A. C.
Thiery, Joachim
Tönjes, Anke
van Dongen, Jenny
van Iterson, Maarten
Veldink, Jan H.
Völker, Uwe
Warmerdam, Robert
Wijmenga, Cisca
Swertz, Morris
Andiappan, Anand
Montgomery, Grant W.
Ripatti, Samuli
Perola, Markus
Kutalik, Zoltan
Dermitzakis, Emmanouil
Bergmann, Sven
van Meurs, Joyce
Prokisch, Holger
Ahsan, Habibul
Pierce, Brandon L.
Lehtimäki, Terho
Psaty, Bruce M.
Gharib, Sina A.
Awadalla, Philip
Milani, Lili
Ouwehand, Willem H.
Downes, Kate
Stegle, Oliver
Battle, Alexis
Visscher, Peter M.
Yang, Jian
Powell, Joseph
Gibson, Greg
Esko, Tõnu
Franke, Lude
i2QTL Consortium
BIOS Consortium
BIOS Consortium
i2QTL Consortium
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_459326
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_459326
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00913-z
