Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma
Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma
About this item
Full title
Author / Creator
Fangazio, Marco , Ladewig, Erik , Gomez, Karen , Garcia-Ibanez, Laura , Kumar, Rahul , Teruya-Feldstein, Julie , Rossi, Davide , Filip, Ioan , Pan-Hammarström, Qiang , Inghirami, Giorgio , Boldorini, Renzo , Ott, German , Staiger, Annette M. , Chapuy, Björn , Gaidano, Gianluca , Bhagat, Govind , Basso, Katia , Rabadan, Raul , Pasqualucci, Laura and Dalla-Favera, Riccardo
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Fifty percent of diffuse large B cell lymphoma (DLBCL) cases lack cell-surface expression of the class I major histocompatibility complex (MHC-I), thus escaping recognition by cytotoxic T cells. Here we show that, across B cell lymphomas, loss of MHC-I, but not MHC-II, is preferentially restricted to DLBCL. To identify the involved mechanisms, we p...
Alternative Titles
Full title
Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma
Authors, Artists and Contributors
Author / Creator
Ladewig, Erik
Gomez, Karen
Garcia-Ibanez, Laura
Kumar, Rahul
Teruya-Feldstein, Julie
Rossi, Davide
Filip, Ioan
Pan-Hammarström, Qiang
Inghirami, Giorgio
Boldorini, Renzo
Ott, German
Staiger, Annette M.
Chapuy, Björn
Gaidano, Gianluca
Bhagat, Govind
Basso, Katia
Rabadan, Raul
Pasqualucci, Laura
Dalla-Favera, Riccardo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_461680
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_461680
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2104504118
