Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
About this item
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Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-phenylpyridinium (MPP +) leads to the degeneration of dopaminergic neurons in man and rodents. To formally describe this mechanism of toxicity, an adverse outcome pathway (AOP:3) has been developed that implies that any inhibitor of cI, or possibly of other p...
Alternative Titles
Full title
Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
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Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_464761
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_464761
Other Identifiers
ISSN
0340-5761,1432-0738
E-ISSN
1432-0738
DOI
10.1007/s00204-020-02970-5
