The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs...
The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The pancreatic tumour stroma is composed of phenotypically heterogenous cancer-associated fibroblasts (CAFs) with both pro- and anti-tumorigenic functions. Here, we studied the impact of calcipotriol, a vitamin D
3
analogue, on the activation of human pancreatic CAFs and T cells using 2- and 3-dimensional (2D, 3D) cell culture models. We foun...
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Full title
The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity
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TN_cdi_swepub_primary_oai_swepub_ki_se_467328
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_467328
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-74368-3
