Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascular...
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips
About this item
Full title
Author / Creator
Herland, Anna , Maoz, Ben M. , Das, Debarun , Somayaji, Mahadevabharath R. , Prantil-Baun, Rachelle , Novak, Richard , Cronce, Michael , Huffstater, Tessa , Jeanty, Sauveur S. F. , Ingram, Miles , Chalkiadaki, Angeliki , Benson Chou, David , Marquez, Susan , Delahanty, Aaron , Jalili-Firoozinezhad, Sasan , Milton, Yuka , Sontheimer-Phelps, Alexandra , Swenor, Ben , Levy, Oren , Parker, Kevin K. , Przekwas, Andrzej and Ingber, Donald E.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. Here, we show that physiological PK modelling of first-pass drug absorption, metabolism and excretion in humans—using computatio...
Alternative Titles
Full title
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips
Authors, Artists and Contributors
Author / Creator
Maoz, Ben M.
Das, Debarun
Somayaji, Mahadevabharath R.
Prantil-Baun, Rachelle
Novak, Richard
Cronce, Michael
Huffstater, Tessa
Jeanty, Sauveur S. F.
Ingram, Miles
Chalkiadaki, Angeliki
Benson Chou, David
Marquez, Susan
Delahanty, Aaron
Jalili-Firoozinezhad, Sasan
Milton, Yuka
Sontheimer-Phelps, Alexandra
Swenor, Ben
Levy, Oren
Parker, Kevin K.
Przekwas, Andrzej
Ingber, Donald E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_473966
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_473966
Other Identifiers
ISSN
2157-846X
E-ISSN
2157-846X
DOI
10.1038/s41551-019-0498-9
