Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
About this item
Full title
Author / Creator
Pentinmikko, Nalle , Iqbal, Sharif , Mana, Miyeko , Andersson, Simon , Cognetta, Armand B. , Suciu, Radu M. , Roper, Jatin , Luopajärvi, Kalle , Markelin, Eino , Gopalakrishnan, Swetha , Smolander, Olli-Pekka , Naranjo, Santiago , Saarinen, Tuure , Juuti, Anne , Pietiläinen, Kirsi , Auvinen, Petri , Ristimäki, Ari , Gupta, Nitin , Tammela, Tuomas , Jacks, Tyler , Sabatini, David M. , Cravatt, Benjamin F. , Yilmaz, Ömer H. and Katajisto, Pekka
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A decline in stem cell function impairs tissue regeneration during ageing, but the role of the stem-cell-supporting niche in ageing is not well understood. The small intestine is maintained by actively cycling intestinal stem cells that are regulated by the Paneth cell niche
1
,
2
. Here we show that the regenerative potential of human...
Alternative Titles
Full title
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
Authors, Artists and Contributors
Author / Creator
Iqbal, Sharif
Mana, Miyeko
Andersson, Simon
Cognetta, Armand B.
Suciu, Radu M.
Roper, Jatin
Luopajärvi, Kalle
Markelin, Eino
Gopalakrishnan, Swetha
Smolander, Olli-Pekka
Naranjo, Santiago
Saarinen, Tuure
Juuti, Anne
Pietiläinen, Kirsi
Auvinen, Petri
Ristimäki, Ari
Gupta, Nitin
Tammela, Tuomas
Jacks, Tyler
Sabatini, David M.
Cravatt, Benjamin F.
Yilmaz, Ömer H.
Katajisto, Pekka
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_478477
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_478477
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1383-0
