Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and pr...
Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations
About this item
Full title
Author / Creator
Dellino, Gaetano Ivan , Palluzzi, Fernando , Chiariello, Andrea Maria , Piccioni, Rossana , Bianco, Simona , Furia, Laura , De Conti, Giulia , Bouwman, Britta A. M. , Melloni, Giorgio , Guido, Davide , Giacò, Luciano , Luzi, Lucilla , Cittaro, Davide , Faretta, Mario , Nicodemi, Mario , Crosetto, Nicola and Pelicci, Pier Giuseppe
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
It is not clear how spontaneous DNA double-strand breaks (DSBs) form and are processed in normal cells, and whether they predispose to cancer-associated translocations. We show that DSBs in normal mammary cells form upon release of paused RNA polymerase II (Pol II) at promoters, 5′ splice sites and active enhancers, and are processed by end-joining...
Alternative Titles
Full title
Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_479687
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_479687
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0421-z
