Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
About this item
Full title
Author / Creator
Visnes, Torkild , Cázares-Körner, Armando , Hao, Wenjing , Wallner, Olov , Masuyer, Geoffrey , Loseva, Olga , Mortusewicz, Oliver , Wiita, Elisée , Sarno, Antonio , Manoilov, Aleksandr , Astorga-Wells, Juan , Jemth, Ann-Sofie , Pan, Lang , Sanjiv, Kumar , Karsten, Stella , Gokturk, Camilla , Grube, Maurice , Homan, Evert J. , Hanna, Bishoy M. F. , Paulin, Cynthia B. J. , Pham, Therese , Rasti, Azita , Berglund, Ulrika Warpman , von Nicolai, Catharina , Benitez-Buelga, Carlos , Koolmeister, Tobias , Ivanic, Dag , Iliev, Petar , Scobie, Martin , Krokan, Hans E. , Baranczewski, Pawel , Artursson, Per , Altun, Mikael , Jensen, Annika Jenmalm , Kalderén, Christina , Ba, Xueqing , Zubarev, Roman A. , Stenmark, Pål , Boldogh, Istvan , Helleday, Thomas , Faculty of Medicine , Medicinska fakulteten , Structural Biochemistry , Department of Experimental Medical Science , Lund University , Strukturell biokemi , Institutionen för experimentell medicinsk vetenskap and Lunds universitet
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: The American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Mice that lack the gene encoding 8-oxoguanine DNA glycosylase 1 (OGG1) show resistance to inflammation. This enzyme binds to sites of oxidative DNA damage and initiates DNA base excision repair. Visnes
et al.
developed a small-molecule drug that acts as a potent and selective active-site inhibitor that stops OGG1 from recognizing its DNA subs...
Alternative Titles
Full title
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Authors, Artists and Contributors
Author / Creator
Cázares-Körner, Armando
Hao, Wenjing
Wallner, Olov
Masuyer, Geoffrey
Loseva, Olga
Mortusewicz, Oliver
Wiita, Elisée
Sarno, Antonio
Manoilov, Aleksandr
Astorga-Wells, Juan
Jemth, Ann-Sofie
Pan, Lang
Sanjiv, Kumar
Karsten, Stella
Gokturk, Camilla
Grube, Maurice
Homan, Evert J.
Hanna, Bishoy M. F.
Paulin, Cynthia B. J.
Pham, Therese
Rasti, Azita
Berglund, Ulrika Warpman
von Nicolai, Catharina
Benitez-Buelga, Carlos
Koolmeister, Tobias
Ivanic, Dag
Iliev, Petar
Scobie, Martin
Krokan, Hans E.
Baranczewski, Pawel
Artursson, Per
Altun, Mikael
Jensen, Annika Jenmalm
Kalderén, Christina
Ba, Xueqing
Zubarev, Roman A.
Stenmark, Pål
Boldogh, Istvan
Helleday, Thomas
Faculty of Medicine
Medicinska fakulteten
Structural Biochemistry
Department of Experimental Medical Science
Lund University
Strukturell biokemi
Institutionen för experimentell medicinsk vetenskap
Lunds universitet
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_484100
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_484100
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.aar8048
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