A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endot...
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
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Author / Creator
Maoz, Ben M , Herland, Anna , FitzGerald, Edward A , Grevesse, Thomas , Vidoudez, Charles , Pacheco, Alan R , Sheehy, Sean P , Park, Tae-Eun , Dauth, Stephanie , Mannix, Robert , Budnik, Nikita , Shores, Kevin , Cho, Alexander , Nawroth, Janna C , Segrè, Daniel , Budnik, Bogdan , Ingber, Donald E and Parker, Kevin Kit
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Three linked microfluidic chips model transport across the blood–brain barrier.
The neurovascular unit (NVU) regulates metabolic homeostasis as well as drug pharmacokinetics and pharmacodynamics in the central nervous system. Metabolic fluxes and conversions over the NVU rely on interactions between brain microvascular endothelium, perivascular...
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Full title
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
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TN_cdi_swepub_primary_oai_swepub_ki_se_486184
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_486184
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ISSN
1087-0156,1546-1696
E-ISSN
1546-1696
DOI
10.1038/nbt.4226
