Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer
Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer
About this item
Full title
Author / Creator
Karlsson, Jenny , Valind, Anders , Holmquist Mengelbier, Linda , Bredin, Sofia , Cornmark, Louise , Jansson, Caroline , Wali, Amina , Staaf, Johan , Viklund, Björn , Øra, Ingrid , Börjesson, Anna , Backman, Torbjörn , Braekeveldt, Noémie , Sandstedt, Bengt , Pal, Niklas , Isaksson, Anders , Lackner, Barbara Gürtl , Jonson, Tord , Bexell, Daniel , Gisselsson, David , Division of Clinical Genetics , Department of Laboratory Medicine , Division of Translational Cancer Research , Pathways of cancer cell evolution , Bröstcancer-genetik , Section I , Department of Clinical Sciences, Lund , Lund University , Avdelningen för translationell cancerforskning , Institutionen för laboratoriemedicin , Sektion V , Section V , Pediatric surgery , Cancercellers evolution , Breastcancer-genetics , Faculty of Medicine , Medicinska fakulteten , Avdelningen för klinisk genetik , Institutionen för kliniska vetenskaper, Lund , Barnkirurgi , Lunds universitet , Sektion I , Childhood Cancer Research Unit , Paediatrics (Lund) and Pediatrik, Lund
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
A major challenge to personalized oncology is that driver mutations vary among cancer cells inhabiting the same tumor. Whether this reflects principally disparate patterns of Darwinian evolution in different tumor regions has remained unexplored
1
–
5
. We mapped the prevalence of genetically distinct clones over 250 regions in 54 child...
Alternative Titles
Full title
Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer
Authors, Artists and Contributors
Author / Creator
Valind, Anders
Holmquist Mengelbier, Linda
Bredin, Sofia
Cornmark, Louise
Jansson, Caroline
Wali, Amina
Staaf, Johan
Viklund, Björn
Øra, Ingrid
Börjesson, Anna
Backman, Torbjörn
Braekeveldt, Noémie
Sandstedt, Bengt
Pal, Niklas
Isaksson, Anders
Lackner, Barbara Gürtl
Jonson, Tord
Bexell, Daniel
Gisselsson, David
Division of Clinical Genetics
Department of Laboratory Medicine
Division of Translational Cancer Research
Pathways of cancer cell evolution
Bröstcancer-genetik
Section I
Department of Clinical Sciences, Lund
Lund University
Avdelningen för translationell cancerforskning
Institutionen för laboratoriemedicin
Sektion V
Section V
Pediatric surgery
Cancercellers evolution
Breastcancer-genetics
Faculty of Medicine
Medicinska fakulteten
Avdelningen för klinisk genetik
Institutionen för kliniska vetenskaper, Lund
Barnkirurgi
Lunds universitet
Sektion I
Childhood Cancer Research Unit
Paediatrics (Lund)
Pediatrik, Lund
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_487887
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_487887
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0131-y
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