Polygenic transmission disequilibrium confirms that common and rare variation act additively to crea...
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
About this item
Full title
Author / Creator
Weiner, Daniel J , Wigdor, Emilie M , Ripke, Stephan , Walters, Raymond K , Kosmicki, Jack A , Grove, Jakob , Samocha, Kaitlin E , Goldstein, Jacqueline I , Okbay, Aysu , Bybjerg-Grauholm, Jonas , Werge, Thomas , Hougaard, David M , Taylor, Jacob , Skuse, David , Devlin, Bernie , Anney, Richard , Sanders, Stephan J , Bishop, Somer , Mortensen, Preben Bo , Børglum, Anders D , Smith, George Davey , Daly, Mark J , Robinson, Elise B , iPSYCH-Broad Autism Group and Psychiatric Genomics Consortium Autism Group
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Elise Robinson and colleagues present the polygenic transmission disequilibrium test (pTDT) for evaluating transmission of polygenic risk in family-based study designs. The authors apply pTDT to a cohort of autism spectrum disorder (ASD) families and find that common polygenic variation acts additively with
de novo
variants to contribute to A...
Alternative Titles
Full title
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Authors, Artists and Contributors
Author / Creator
Wigdor, Emilie M
Ripke, Stephan
Walters, Raymond K
Kosmicki, Jack A
Grove, Jakob
Samocha, Kaitlin E
Goldstein, Jacqueline I
Okbay, Aysu
Bybjerg-Grauholm, Jonas
Werge, Thomas
Hougaard, David M
Taylor, Jacob
Skuse, David
Devlin, Bernie
Anney, Richard
Sanders, Stephan J
Bishop, Somer
Mortensen, Preben Bo
Børglum, Anders D
Smith, George Davey
Daly, Mark J
Robinson, Elise B
iPSYCH-Broad Autism Group
Psychiatric Genomics Consortium Autism Group
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_496815
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_496815
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3863
