A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
About this item
Full title
Author / Creator
Tammela, Tuomas , Sanchez-Rivera, Francisco J. , Cetinbas, Naniye Malli , Wu, Katherine , Joshi, Nikhil S. , Helenius, Katja , Park, Yoona , Azimi, Roxana , Kerper, Natanya R. , Wesselhoeft, R. Alexander , Gu, Xin , Schmidt, Leah , Cornwall-Brady, Milton , Yilmaz, Ömer H. , Xue, Wen , Katajisto, Pekka , Bhutkar, Arjun and Jacks, Tyler
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A subset of Kras and p53 mutant cancer cells acts as a Wnt-producing niche for another cancer cell subset, and porcupine inhibition disrupts Wnt secretion in this niche, thereby suppressing proliferative potential and leading to therapeutic benefit.
Lung cancer niche drives tumour growth
Lung adenocarcinomas are aggressive tumours which are a...
Alternative Titles
Full title
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
Authors, Artists and Contributors
Author / Creator
Sanchez-Rivera, Francisco J.
Cetinbas, Naniye Malli
Wu, Katherine
Joshi, Nikhil S.
Helenius, Katja
Park, Yoona
Azimi, Roxana
Kerper, Natanya R.
Wesselhoeft, R. Alexander
Gu, Xin
Schmidt, Leah
Cornwall-Brady, Milton
Yilmaz, Ömer H.
Xue, Wen
Katajisto, Pekka
Bhutkar, Arjun
Jacks, Tyler
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_496904
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_496904
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22334
