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S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_501394

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

About this item

Full title

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2016-12, Vol.540 (7632), p.236-241

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

R
-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of
R
-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both metabolite enantiomers,
R
- and
S
-2-hydroxyglutarate, are detectible in healthy individuals, yet their phy...

Alternative Titles

Full title

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_swepub_ki_se_501394

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_501394

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature20165

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