S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
R
-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of
R
-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both metabolite enantiomers,
R
- and
S
-2-hydroxyglutarate, are detectible in healthy individuals, yet their phy...
Alternative Titles
Full title
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_501394
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_501394
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature20165
