Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Yu Chen and colleagues describe a new constitutively activating mutation in the G-protein-coupled receptor
CYSLTR2
in patients with uveal melanoma lacking mutations in the G-protein-encoding genes
GNAQ
and
GNA11
. They find that expression of the mutant leads to increased expression of melanocyte-lineage signature genes and promot...
Alternative Titles
Full title
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma
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Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_505793
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_505793
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3549
