Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis
Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis
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Publisher
England: Elsevier Limited
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Language
English
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Publisher
England: Elsevier Limited
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ObjectivesIt has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging and in a post-traumatic model.MethodsMice lacking th...
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Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis
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TN_cdi_swepub_primary_oai_swepub_ki_se_510220
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_510220
Other Identifiers
ISSN
0003-4967
E-ISSN
1468-2060
DOI
10.1136/annrheumdis-2015-207742
