Class II HLA interactions modulate genetic risk for multiple sclerosis
Class II HLA interactions modulate genetic risk for multiple sclerosis
About this item
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Author / Creator
Moutsianas, Loukas , Jostins, Luke , Beecham, Ashley H , Dilthey, Alexander T , Xifara, Dionysia K , Ban, Maria , Shah, Tejas S , Patsopoulos, Nikolaos A , Alfredsson, Lars , Anderson, Carl A , Attfield, Katherine E , Baranzini, Sergio E , Barrett, Jeffrey , Binder, Thomas M C , Booth, David , Buck, Dorothea , Celius, Elisabeth G , Cotsapas, Chris , D'Alfonso, Sandra , Dendrou, Calliope A , Donnelly, Peter , Dubois, Bénédicte , Fontaine, Bertrand , Fugger, Lars , Goris, An , Gourraud, Pierre-Antoine , Graetz, Christiane , Hemmer, Bernhard , Hillert, Jan , Kockum, Ingrid , Leslie, Stephen , Lill, Christina M , Martinelli-Boneschi, Filippo , Oksenberg, Jorge R , Olsson, Tomas , Oturai, Annette , Saarela, Janna , Søndergaard, Helle Bach , Spurkland, Anne , Taylor, Bruce , Winkelmann, Juliane , Zipp, Frauke , Haines, Jonathan L , Pericak-Vance, Margaret A , Spencer, Chris C A , Stewart, Graeme , Hafler, David A , Ivinson, Adrian J , Harbo, Hanne F , Hauser, Stephen L , De Jager, Philip L , Compston, Alastair , McCauley, Jacob L , Sawcer, Stephen , McVean, Gil , the International Multiple Sclerosis Genetics Consortium and International IBD Genetics Consortium (IIBDGC)
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Gil McVean and colleagues report a meta-analysis of Immunochip studies including over 17,000 multiple sclerosis cases and 30,000 controls, with imputation of classical HLA alleles. They find two interactions involving class II HLA alleles but no evidence for significant epistatic interactions or interactions between HLA and non-HLA risk variants.
Alternative Titles
Full title
Class II HLA interactions modulate genetic risk for multiple sclerosis
Authors, Artists and Contributors
Author / Creator
Jostins, Luke
Beecham, Ashley H
Dilthey, Alexander T
Xifara, Dionysia K
Ban, Maria
Shah, Tejas S
Patsopoulos, Nikolaos A
Alfredsson, Lars
Anderson, Carl A
Attfield, Katherine E
Baranzini, Sergio E
Barrett, Jeffrey
Binder, Thomas M C
Booth, David
Buck, Dorothea
Celius, Elisabeth G
Cotsapas, Chris
D'Alfonso, Sandra
Dendrou, Calliope A
Donnelly, Peter
Dubois, Bénédicte
Fontaine, Bertrand
Fugger, Lars
Goris, An
Gourraud, Pierre-Antoine
Graetz, Christiane
Hemmer, Bernhard
Hillert, Jan
Kockum, Ingrid
Leslie, Stephen
Lill, Christina M
Martinelli-Boneschi, Filippo
Oksenberg, Jorge R
Olsson, Tomas
Oturai, Annette
Saarela, Janna
Søndergaard, Helle Bach
Spurkland, Anne
Taylor, Bruce
Winkelmann, Juliane
Zipp, Frauke
Haines, Jonathan L
Pericak-Vance, Margaret A
Spencer, Chris C A
Stewart, Graeme
Hafler, David A
Ivinson, Adrian J
Harbo, Hanne F
Hauser, Stephen L
De Jager, Philip L
Compston, Alastair
McCauley, Jacob L
Sawcer, Stephen
McVean, Gil
the International Multiple Sclerosis Genetics Consortium
International IBD Genetics Consortium (IIBDGC)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_510893
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_510893
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3395
