Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures
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Author / Creator
Movérare-Skrtic, Sofia , Henning, Petra , Liu, Xianwen , Nagano, Kenichi , Saito, Hiroaki , Börjesson, Anna E , Sjögren, Klara , Windahl, Sara H , Farman, Helen , Kindlund, Bert , Engdahl, Cecilia , Koskela, Antti , Zhang, Fu-Ping , Eriksson, Emma E , Zaman, Farasat , Hammarstedt, Ann , Isaksson, Hanna , Bally, Marta , Kassem, Ali , Lindholm, Catharina , Sandberg, Olof , Aspenberg, Per , Sävendahl, Lars , Feng, Jian Q , Tuckermann, Jan , Tuukkanen, Juha , Poutanen, Matti , Baron, Roland , Lerner, Ulf H , Gori, Francesca , Ohlsson, Claes , Faculty of Engineering, LTH , Avdelningen för biomedicinsk teknik , Division for Biomedical Engineering , Lund University , Department of Biomedical Engineering , Institutioner vid LTH , Institutionen för biomedicinsk teknik , Lunds Tekniska Högskola , Departments at LTH and Lunds universitet
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A new study shows that Wnt16 inhibits osteoclast formation, suggesting it may be a possible therapeutic option for treating bone fractures in osteoporosis.
The
WNT16
locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced nonvertebr...
Alternative Titles
Full title
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures
Authors, Artists and Contributors
Author / Creator
Henning, Petra
Liu, Xianwen
Nagano, Kenichi
Saito, Hiroaki
Börjesson, Anna E
Sjögren, Klara
Windahl, Sara H
Farman, Helen
Kindlund, Bert
Engdahl, Cecilia
Koskela, Antti
Zhang, Fu-Ping
Eriksson, Emma E
Zaman, Farasat
Hammarstedt, Ann
Isaksson, Hanna
Bally, Marta
Kassem, Ali
Lindholm, Catharina
Sandberg, Olof
Aspenberg, Per
Sävendahl, Lars
Feng, Jian Q
Tuckermann, Jan
Tuukkanen, Juha
Poutanen, Matti
Baron, Roland
Lerner, Ulf H
Gori, Francesca
Ohlsson, Claes
Faculty of Engineering, LTH
Avdelningen för biomedicinsk teknik
Division for Biomedical Engineering
Lund University
Department of Biomedical Engineering
Institutioner vid LTH
Institutionen för biomedicinsk teknik
Lunds Tekniska Högskola
Departments at LTH
Lunds universitet
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_518307
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_518307
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/nm.3654
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