Tracking cancer drugs in living cells by thermal profiling of the proteome
Tracking cancer drugs in living cells by thermal profiling of the proteome
About this item
Full title
Author / Creator
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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More information
Scope and Contents
Contents
To understand both the beneficial and the side effects of a drug, one would need to know its full binding profile to all cellular proteins. Savitski
et al.
take significant steps toward meeting this daunting challenge. They monitored the unfolding or “melting” of over 7000 human proteins and measured how small-molecule binding changes individ...
Alternative Titles
Full title
Tracking cancer drugs in living cells by thermal profiling of the proteome
Authors, Artists and Contributors
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Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_518477
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_518477
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1255784
