Recurrent mutations refine prognosis in chronic lymphocytic leukemia

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_520821

Recurrent mutations refine prognosis in chronic lymphocytic leukemia

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Baliakas, P , Hadzidimitriou, A , Sutton, L-A , Rossi, D , Minga, E , Villamor, N , Larrayoz, M , Kminkova, J , Agathangelidis, A , Davis, Z , Tausch, E , Stalika, E , Kantorova, B , Mansouri, L , Scarfò, L , Cortese, D , Navrkalova, V , Rose-Zerilli, M J J , Smedby, K E , Juliusson, G , Anagnostopoulos, A , Makris, A M , Navarro, A , Delgado, J , Oscier, D , Belessi, C , Stilgenbauer, S , Ghia, P , Pospisilova, S , Gaidano, G , Campo, E , Strefford, J C , Stamatopoulos, K , Rosenquist, R , on behalf of the European Research Initiative on CLL (ERIC) , European Research Initiative on CLL (ERIC) , Faculty of Medicine , Division of stem cell research , Medicinska fakulteten , Lund University , Institutionen för laboratoriemedicin , Department of Laboratory Medicine , Stem Cell Center , Stamcellscentrum (SCC) , Lunds universitet and Avdelningen för stamcellsforskning

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London: Nature Publishing Group UK

Journal title

Leukemia, 2015-02, Vol.29 (2), p.329-336

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English

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Publisher

London: Nature Publishing Group UK

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Contents

Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (ERIC), we screened 3490 patients with CLL for mutations within the
NOTCH1
(
n
=3334),
SF3B1
(
n
=2322),
TP53
(
n
=2309),
MYD88
(
n
=1080) and
BIRC3
(
n
=919) genes, mainly at diagnosis (75%) and before treatmen...