A polygenic burden of rare disruptive mutations in schizophrenia
A polygenic burden of rare disruptive mutations in schizophrenia
About this item
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Author / Creator
Purcell, Shaun M. , Moran, Jennifer L. , Fromer, Menachem , Ruderfer, Douglas , Solovieff, Nadia , Roussos, Panos , O’Dushlaine, Colm , Chambert, Kimberly , Bergen, Sarah E. , Kähler, Anna , Duncan, Laramie , Stahl, Eli , Genovese, Giulio , Fernández, Esperanza , Collins, Mark O. , Komiyama, Noboru H. , Choudhary, Jyoti S. , Magnusson, Patrik K. E. , Banks, Eric , Shakir, Khalid , Garimella, Kiran , Fennell, Tim , DePristo, Mark , Grant, Seth G. N. , Haggarty, Stephen J. , Gabriel, Stacey , Scolnick, Edward M. , Lander, Eric S. , Hultman, Christina M. , Sullivan, Patrick F. , McCarroll, Steven A. and Sklar, Pamela
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Schizophrenia is a common disease with a complex aetiology, probably involving multiple and heterogeneous genetic factors. Here, by analysing the exome sequences of 2,536 schizophrenia cases and 2,543 controls, we demonstrate a polygenic burden primarily arising from rare (less than 1 in 10,000), disruptive mutations distributed across many genes....
Alternative Titles
Full title
A polygenic burden of rare disruptive mutations in schizophrenia
Authors, Artists and Contributors
Author / Creator
Moran, Jennifer L.
Fromer, Menachem
Ruderfer, Douglas
Solovieff, Nadia
Roussos, Panos
O’Dushlaine, Colm
Chambert, Kimberly
Bergen, Sarah E.
Kähler, Anna
Duncan, Laramie
Stahl, Eli
Genovese, Giulio
Fernández, Esperanza
Collins, Mark O.
Komiyama, Noboru H.
Choudhary, Jyoti S.
Magnusson, Patrik K. E.
Banks, Eric
Shakir, Khalid
Garimella, Kiran
Fennell, Tim
DePristo, Mark
Grant, Seth G. N.
Haggarty, Stephen J.
Gabriel, Stacey
Scolnick, Edward M.
Lander, Eric S.
Hultman, Christina M.
Sullivan, Patrick F.
McCarroll, Steven A.
Sklar, Pamela
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_524097
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_524097
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12975
