Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The transcription factor HIF is induced in response to hypoxic stress, TCR activation and cytokines. Goldrath and colleagues show that HIF signaling enhances CTL effector responses and can render cells refractory to immune exhaustion.
Cytolytic activity by CD8
+
cytotoxic T lymphocytes (CTLs) is a powerful strategy for the elimination of i...
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Full title
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
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TN_cdi_swepub_primary_oai_swepub_ki_se_526612
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_526612
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.2714
