Novel role of PKR in inflammasome activation and HMGB1 release
Novel role of PKR in inflammasome activation and HMGB1 release
About this item
Full title
Author / Creator
Lu, Ben , Nakamura, Takahisa , Inouye, Karen , Li, Jianhua , Tang, Yiting , Lundbäck, Peter , Valdes-Ferrer, Sergio I. , Olofsson, Peder S. , Kalb, Thomas , Roth, Jesse , Zou, Yongrui , Erlandsson-Harris, Helena , Yang, Huan , Ting, Jenny P.-Y. , Wang, Haichao , Andersson, Ulf , Antoine, Daniel J. , Chavan, Sangeeta S. , Hotamisligil, Gökhan S. and Tracey, Kevin J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release of interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1) in response to a diverse range of stimuli.
Modulation of inflammasome activation
The inflammasome, an intracellular o...
Alternative Titles
Full title
Novel role of PKR in inflammasome activation and HMGB1 release
Authors, Artists and Contributors
Author / Creator
Nakamura, Takahisa
Inouye, Karen
Li, Jianhua
Tang, Yiting
Lundbäck, Peter
Valdes-Ferrer, Sergio I.
Olofsson, Peder S.
Kalb, Thomas
Roth, Jesse
Zou, Yongrui
Erlandsson-Harris, Helena
Yang, Huan
Ting, Jenny P.-Y.
Wang, Haichao
Andersson, Ulf
Antoine, Daniel J.
Chavan, Sangeeta S.
Hotamisligil, Gökhan S.
Tracey, Kevin J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_535868
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_535868
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11290
