Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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PARP inhibitors have recently entered phase 3 clinical trials as cancer therapeutics, but the specificity of many of these compounds is unknown. Wahlberg
et al
. used biochemical approaches to show that most PARP inhibitors target multiple PARP family members.
Inhibitors of poly-ADP-ribose polymerase (PARP) family proteins are currently in...
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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
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TN_cdi_swepub_primary_oai_swepub_ki_se_538934
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_538934
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.2121
