TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in br...
TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial
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Author / Creator
Bonnefoi, Hervé, Prof , Piccart, Martine, Prof , Bogaerts, Jan, PhD , Mauriac, Louis, MD , Fumoleau, Pierre, Prof , Brain, Etienne, MD , Petit, Thierry, Prof , Rouanet, Philippe, Prof , Jassem, Jacek, Prof , Blot, Emmanuel, MD , Zaman, Khalil, MD , Cufer, Tanja, Prof , Lortholary, Alain, MD , Lidbrink, Elisabet, MD , André, Sylvie , Litière, Saskia, PhD , Lago, Lissandra Dal, MD , Becette, Véronique, MD , Cameron, David A, Prof , Bergh, Jonas, Prof , Iggo, Richard, Prof , on behalf of the EORTC 10994/BIG 1-00 Study Investigators and EORTC 10994/BIG 1-00 Study Investigators
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publisher
England: Elsevier Ltd
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Scope and Contents
Contents
SummaryBackgroundTP53 has a crucial role in the DNA damage response. We therefore tested the hypothesis that taxanes confer a greater advantage than do anthracyclines on breast cancers with mutated TP53 than in those with wild-type TP53. MethodsIn an open-label, phase 3 study, women (age <71 years) with locally advanced, inflammatory, or large oper...
Alternative Titles
Full title
TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial
Authors, Artists and Contributors
Author / Creator
Piccart, Martine, Prof
Bogaerts, Jan, PhD
Mauriac, Louis, MD
Fumoleau, Pierre, Prof
Brain, Etienne, MD
Petit, Thierry, Prof
Rouanet, Philippe, Prof
Jassem, Jacek, Prof
Blot, Emmanuel, MD
Zaman, Khalil, MD
Cufer, Tanja, Prof
Lortholary, Alain, MD
Lidbrink, Elisabet, MD
André, Sylvie
Litière, Saskia, PhD
Lago, Lissandra Dal, MD
Becette, Véronique, MD
Cameron, David A, Prof
Bergh, Jonas, Prof
Iggo, Richard, Prof
on behalf of the EORTC 10994/BIG 1-00 Study Investigators
EORTC 10994/BIG 1-00 Study Investigators
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Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_544330
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_544330
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(11)70094-8
