Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced o...
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization
About this item
Full title
Author / Creator
Fairman, James Wesley , Wijerathna, Sanath Ranjan , Ahmad, Md Faiz , Xu, Hai , Nakano, Ryo , Jha, Shalini , Prendergast, Jay , Welin, R Martin , Flodin, Susanne , Roos, Annette , Nordlund, Pär , Li, Zongli , Walz, Thomas , Dealwis, Chris Godfrey and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Ribonucleotide reductase is essential to maintain the cellular pools of dNTPs, and its activity is controlled allosterically by ATP (activator) and dATP (inhibitor). Now crystal and EM structures of human and yeast ribonucleotide reductase 1 in complex with different nucleotides, together with mutagenesis and functional analysis, reveal how dATP bi...
Alternative Titles
Full title
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization
Authors, Artists and Contributors
Author / Creator
Wijerathna, Sanath Ranjan
Ahmad, Md Faiz
Xu, Hai
Nakano, Ryo
Jha, Shalini
Prendergast, Jay
Welin, R Martin
Flodin, Susanne
Roos, Annette
Nordlund, Pär
Li, Zongli
Walz, Thomas
Dealwis, Chris Godfrey
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_546014
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_546014
Other Identifiers
ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/nsmb.2007
