High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse...
High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event
About this item
Full title
Author / Creator
Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , StemTherapy: National Initiative on Stem Cells for Regenerative Therapy , Department of Laboratory Medicine , Strategic research areas (SRA) , Lunds universitet , Profilområden och andra starka forskningsmiljöer , Lund University , Division of Molecular Medicine and Gene Therapy , Institutionen för laboratoriemedicin , Profile areas and other strong research environments , Avdelningen för molekylärmedicin och genterapi , Quéré, R , Andradottir, S , Brun, A C M , Zubarev, R A , Karlsson, G , Olsson, K , Magnusson, M , Cammenga, J and Karlsson, S
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Multiple genetic hits are detected in patients with acute myeloid leukemia (AML). To investigate this further, we developed a tetracycline-inducible mouse model of AML, in which the initial transforming event, overexpression of
HOXA10
, can be eliminated. Continuous overexpression of
HOXA10
is required to generate AML in primary recipie...
Alternative Titles
Full title
High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event
Authors, Artists and Contributors
Author / Creator
Medicinska fakulteten
Strategiska forskningsområden (SFO)
StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
Department of Laboratory Medicine
Strategic research areas (SRA)
Lunds universitet
Profilområden och andra starka forskningsmiljöer
Lund University
Division of Molecular Medicine and Gene Therapy
Institutionen för laboratoriemedicin
Profile areas and other strong research environments
Avdelningen för molekylärmedicin och genterapi
Quéré, R
Andradottir, S
Brun, A C M
Zubarev, R A
Karlsson, G
Olsson, K
Magnusson, M
Cammenga, J
Karlsson, S
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_547516
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_547516
Other Identifiers
ISSN
0887-6924,1476-5551
E-ISSN
1476-5551
DOI
10.1038/leu.2010.281
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