Cdk2 suppresses cellular senescence induced by the c-myc oncogene
Cdk2 suppresses cellular senescence induced by the c-myc oncogene
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Author / Creator
Campaner, Stefano , Doni, Mirko , Hydbring, Per , Verrecchia, Alessandro , Bianchi, Lucia , Sardella, Domenico , Schleker, Thomas , Perna, Daniele , Tronnersjö, Susanna , Murga, Matilde , Fernandez-Capetillo, Oscar , Barbacid, Mariano , Larsson, Lars-Gunnar , Amati, Bruno and Sveriges lantbruksuniversitet
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Cyclin-dependent kinase 2 (cdk2) is surprisingly found to suppress senescence induced by the
Myc
oncogene in various cell types. Inactivation or deletion of cdk2 sensitizes mouse embryonic fibroblasts to Myc-induced senescence via a mechanism requiring pRb and p53.
Activated oncogenes induce compensatory tumour-suppressive responses, such...
Alternative Titles
Full title
Cdk2 suppresses cellular senescence induced by the c-myc oncogene
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_554183
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_554183
Other Identifiers
ISSN
1465-7392,1476-4679
E-ISSN
1476-4679
DOI
10.1038/ncb2004
