Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during i...
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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tPA is a clot-buster used to treat stroke, but if it's given too late after stroke onset, it can cause complications like hemorrhage. Daniel Lawrence and his colleagues show that a US Food and Drug Administration–approved kinase inhibitor, Gleevec, can prevent this side effect, thereby extending tPA's therapeutic window.
Thrombolytic treatment o...
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Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
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TN_cdi_swepub_primary_oai_swepub_ki_se_563706
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_563706
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1787
