Metabolic control of DNA methylation in naive pluripotent cells
Metabolic control of DNA methylation in naive pluripotent cells
About this item
Full title
Author / Creator
Betto, Riccardo M. , Diamante, Linda , Perrera, Valentina , Audano, Matteo , Rapelli, Stefania , Lauria, Andrea , Incarnato, Danny , Arboit, Mattia , Pedretti, Silvia , Rigoni, Giovanni , Guerineau, Vincent , Touboul, David , Stirparo, Giuliano Giuseppe , Lohoff, Tim , Boroviak, Thorsten , Grumati, Paolo , Soriano, Maria E. , Nichols, Jennifer , Mitro, Nico , Oliviero, Salvatore and Martello, Graziano
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental plasticity is associated with genome hypomethylation. Here, we show that LIF–Stat3 signaling induces genomic hypomethylation via metabolic reconfiguration.
Stat3
−/−
ESCs show decreased α-ketoglutarate production from glutamine, leading to i...
Alternative Titles
Full title
Metabolic control of DNA methylation in naive pluripotent cells
Authors, Artists and Contributors
Author / Creator
Diamante, Linda
Perrera, Valentina
Audano, Matteo
Rapelli, Stefania
Lauria, Andrea
Incarnato, Danny
Arboit, Mattia
Pedretti, Silvia
Rigoni, Giovanni
Guerineau, Vincent
Touboul, David
Stirparo, Giuliano Giuseppe
Lohoff, Tim
Boroviak, Thorsten
Grumati, Paolo
Soriano, Maria E.
Nichols, Jennifer
Mitro, Nico
Oliviero, Salvatore
Martello, Graziano
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_676719
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_676719
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-020-00770-2
