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Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lympho...

Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lympho...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_843910

Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia

About this item

Full title

Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia

Publisher

London: Nature Publishing Group UK

Journal title

Leukemia, 2024-04, Vol.38 (4), p.712-719

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Asparaginase is an essential component of acute lymphoblastic leukemia (ALL) therapy, yet its associated toxicities often lead to treatment discontinuation, increasing the risk of relapse. Hypersensitivity reactions include clinical allergies, silent inactivation, or allergy-like responses. We hypothesized that even moderate increases in asparagina...

Alternative Titles

Full title

Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_swepub_ki_se_843910

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_843910

Other Identifiers

ISSN

0887-6924,1476-5551

E-ISSN

1476-5551

DOI

10.1038/s41375-024-02153-6