p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-co...
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial
About this item
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
p75 neurotrophin receptor (p75
NTR
) signaling pathways substantially overlap with degenerative networks active in Alzheimer disease (AD). Modulation of p75
NTR
with the first-in-class small molecule LM11A-31 mitigates amyloid-induced and pathological tau-induced synaptic loss in preclinical models. Here we conducted a 26-week randomize...
Alternative Titles
Full title
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial
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Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_868347
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_868347
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/s41591-024-02977-w
