Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
About this item
Full title
Author / Creator
AOGC Consortium , UK10K Consortium , Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , Ortopedi , EpiHealth: Epidemiology for Health , Institutionen för kliniska vetenskaper, Malmö , Strategic research areas (SRA) , Lunds universitet , Profilområden och andra starka forskningsmiljöer , Lund University , Profile areas and other strong research environments , Orthopedics , Department of Clinical Sciences, Malmö , Forgetta, Vincenzo , Estrada, Karol , Leo, Paul J. , Dahia, Chitra L. , Liu, Ching‐Ti , Uggla, Charlotta , Evans, Daniel S. , Walter, Klaudia , Pettersson‐Kymmer, Ulrika , McCarthy, Shane , Kwan, Tony , Jhamai, Mila , Trajanoska, Katerina , Huang, Jie , Danecek, Petr , Wilmot, Beth , Li, Rui , Moayyeri, Alireza , Claussnitzer, Melina , Cheng, Chia‐Ho , Cheung, Warren , Ge, Bing , Chen, Shu‐Huang , Choi, Kwangbom , Oei, Ling , Fraser, James , Hibbs, Matthew A. , Gregson, Celia L. , Paquette, Denis , Wibom, Carl , Tranah, Gregory J. , Marshall, Mhairi , Gardiner, Brooke B. , Cremin, Katie , Auer, Paul , Hsu, Li , Thorleifsson, Gudmar , Enneman, Anke W. , de Groot, Lisette C. P. G. M. , Melin, Beatrice , Christiansen, Claus , Sayers, Adrian , Zhou, Yanhua , Calderari, Sophie , van Rooij, Jeroen , Carlson, Chris , Peters, Ulrike , Uitterlinden, Andre G. , Williams, Stephen R. , Farber, Charles , Grinberg, Daniel , Chasman, Daniel I. , Giulianini, Franco , Ridker, Paul M. , Eisman, John A. , Nguyen, Tuan V. , Center, Jacqueline R. , Garcia‐Giralt, Natalia , Mellström, Dan , Vandenput, Liesbeth , Amin, Najaf , van Duijn, Cornelia M. , Karlsson, Magnus K. , Svensson, Olle , Rousseau, François , Bussière, Johanne , Koromani, Fjorda , Langdahl, Bente L. , Jensen, Jens‐Erik B. , Kaptoge, Stephen , Khaw, Kay‐Tee , Reeve, Jonathan , Xuereb‐Anastasi, Angela , Åkesson, Kristina , Olmos, Jose M. , Zarrabeitia, Maria T. , Riancho, Jose A. , Alonso, Nerea , Jiang, Xi , Goltzman, David , Grundberg, Elin , Gauguier, Dominique , Orwoll, Eric S. , Karasik, David , Davey‐Smith, George , Smith, Albert V. , Harris, Tamara B. , Carola Zillikens, M. , Thorsteinsdottir, Unnur , Soranzo, Nicole , Durbin, Richard , Brown, Matthew A. , Spector, Tim , Adrienne Cupples, L. , Greenwood, Celia M. T. , Jackson, Rebecca D. , Rowe, David W. , Loomis, Cynthia A. , Ackert‐Bicknell, Cheryl L. and Kiel, Douglas P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Human population genomic studies, including whole‐genome sequencing, were undertaken to identify determinants of bone mineral density (BMD), a major predictor of osteoporotic fractures. Non‐coding variants with large effects on BMD and fractures were identified near the
EN1
locus and mouse studies confirmed this gene has an important role in...
Alternative Titles
Full title
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
Authors, Artists and Contributors
Author / Creator
UK10K Consortium
Faculty of Medicine
Medicinska fakulteten
Strategiska forskningsområden (SFO)
Ortopedi
EpiHealth: Epidemiology for Health
Institutionen för kliniska vetenskaper, Malmö
Strategic research areas (SRA)
Lunds universitet
Profilområden och andra starka forskningsmiljöer
Lund University
Profile areas and other strong research environments
Orthopedics
Department of Clinical Sciences, Malmö
Forgetta, Vincenzo
Estrada, Karol
Leo, Paul J.
Dahia, Chitra L.
Liu, Ching‐Ti
Uggla, Charlotta
Evans, Daniel S.
Walter, Klaudia
Pettersson‐Kymmer, Ulrika
McCarthy, Shane
Kwan, Tony
Jhamai, Mila
Trajanoska, Katerina
Huang, Jie
Danecek, Petr
Wilmot, Beth
Li, Rui
Moayyeri, Alireza
Claussnitzer, Melina
Cheng, Chia‐Ho
Cheung, Warren
Ge, Bing
Chen, Shu‐Huang
Choi, Kwangbom
Oei, Ling
Fraser, James
Hibbs, Matthew A.
Gregson, Celia L.
Paquette, Denis
Wibom, Carl
Tranah, Gregory J.
Marshall, Mhairi
Gardiner, Brooke B.
Cremin, Katie
Auer, Paul
Hsu, Li
Thorleifsson, Gudmar
Enneman, Anke W.
de Groot, Lisette C. P. G. M.
Melin, Beatrice
Christiansen, Claus
Sayers, Adrian
Zhou, Yanhua
Calderari, Sophie
van Rooij, Jeroen
Carlson, Chris
Peters, Ulrike
Uitterlinden, Andre G.
Williams, Stephen R.
Farber, Charles
Grinberg, Daniel
Chasman, Daniel I.
Giulianini, Franco
Ridker, Paul M.
Eisman, John A.
Nguyen, Tuan V.
Center, Jacqueline R.
Garcia‐Giralt, Natalia
Mellström, Dan
Vandenput, Liesbeth
Amin, Najaf
van Duijn, Cornelia M.
Karlsson, Magnus K.
Svensson, Olle
Rousseau, François
Bussière, Johanne
Koromani, Fjorda
Langdahl, Bente L.
Jensen, Jens‐Erik B.
Kaptoge, Stephen
Khaw, Kay‐Tee
Reeve, Jonathan
Xuereb‐Anastasi, Angela
Åkesson, Kristina
Olmos, Jose M.
Zarrabeitia, Maria T.
Riancho, Jose A.
Alonso, Nerea
Jiang, Xi
Goltzman, David
Grundberg, Elin
Gauguier, Dominique
Orwoll, Eric S.
Karasik, David
Davey‐Smith, George
Smith, Albert V.
Harris, Tamara B.
Carola Zillikens, M.
Thorsteinsdottir, Unnur
Soranzo, Nicole
Durbin, Richard
Brown, Matthew A.
Spector, Tim
Adrienne Cupples, L.
Greenwood, Celia M. T.
Jackson, Rebecca D.
Rowe, David W.
Loomis, Cynthia A.
Ackert‐Bicknell, Cheryl L.
Kiel, Douglas P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_wageningen_narcis_oai_library_wur_nl_wurpubs_492522
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wageningen_narcis_oai_library_wur_nl_wurpubs_492522
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/nature14878
How to access this item
ERROR: Invalid URL specified.
