Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone...
Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss
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Author / Creator
Publisher
Department of Internal Medicine 3,Friedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universit?tsklinikum Erlangen,Erlangen 91054,Germany
Journal title
Language
English
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Publication information
Publisher
Department of Internal Medicine 3,Friedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universit?tsklinikum Erlangen,Erlangen 91054,Germany
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Scope and Contents
Contents
In the bone marrow,B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment.How B cells functionally influence osteoclasts and bone architecture is poorly understood.Using genetically modified mice and high-throughput analyses,we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production...
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Full title
Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss
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Record Identifier
TN_cdi_wanfang_journals_gyj_e202202009
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_gyj_e202202009
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ISSN
2095-4700
