姜黄素对大鼠脊髓Toll样受体4活化及吗啡镇痛耐受的影响
姜黄素对大鼠脊髓Toll样受体4活化及吗啡镇痛耐受的影响
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Beijing: People's Military Medical Press
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Chinese
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Beijing: People's Military Medical Press
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目的观察姜黄素对大鼠脊髓Toll样受体4（TLR4）活化及吗啡镇痛慢性耐受的影响并探讨其作用机制。方法健康清洁级SD大鼠60只,成功鞘内置管后随机分为生理盐水（NS）组、吗啡（MOR）组、姜黄素（Cur）组和吗啡＋姜黄素（MOR＋Cur）组,每组15只。MOR组和MOR＋Cur组连续7d鞘内注射15μg吗啡建立吗啡慢性耐受动物模型,Cur组及MOR＋Cur组连续7d鞘内注射100μg姜黄素,NS组连续7d鞘内注射10μl生理盐水。应用甩尾潜伏期法（TFL）及机械反射阈值法（MWT）观察鞘内注射姜黄素对吗啡镇痛耐受的影响并计算最大镇痛效应（MPE）;应用免疫组织荧光染色法检测姜黄素对腰段脊髓小胶质细胞活化的影响;应用Real-time PCR及Western blotting检测姜黄素对腰段脊...
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姜黄素对大鼠脊髓Toll样受体4活化及吗啡镇痛耐受的影响
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TN_cdi_wanfang_journals_jfjyxzz201712006
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_jfjyxzz201712006
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ISSN
0577-7402
DOI
10.11855/j.issn.0577-7402.2017.12.06
