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姜黄素对小鼠实验性自身免疫性脑脊髓炎的自噬调节及抗炎作用

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姜黄素对小鼠实验性自身免疫性脑脊髓炎的自噬调节及抗炎作用

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_jfjyxzz201907010

姜黄素对小鼠实验性自身免疫性脑脊髓炎的自噬调节及抗炎作用

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Full title

姜黄素对小鼠实验性自身免疫性脑脊髓炎的自噬调节及抗炎作用

Author / Creator

鲍彩彩 , 原铂尧 , 孙梦娇 , 王满侠 , 亓斐 and 牛彦霞

Publisher

730000,兰州 兰州大学第二医院神经内科

Journal title

解放军医学杂志, 2019, Vol.44 (7), p.593-599

Language

Chinese

Formats

Articles

Publication information

Publisher

730000,兰州 兰州大学第二医院神经内科

More information

Scope and Contents

Contents

R74.02; 目的 观察姜黄素对小鼠实验性自身免疫性脑脊髓炎(EAE)的抗炎作用,并初步探究其作用机制.方法 40只雌性C57BL/6小鼠,随机分为EAE+DMSO组、EAE+姜黄素组、DMSO组、姜黄素组4组,每组10只,其中EAE+DMSO组、EAE+姜黄素组建立EAE模型;DMSO组作为EAE+DMSO组的溶剂对照组,此两组小鼠自免疫日起1周后每日腹腔注射20％DMSO溶液0.2 ml;姜黄素组及EAE+姜黄素组小鼠自免疫日起1周后每日腹腔注射姜黄素溶液10 mg/kg.自免疫日起,每天对各组小鼠进行临床症状评分;于EAE发病高峰期(第21天)将小鼠麻醉后处死,取脊髓组织进行HE染色;ELISA法测定各组小鼠血清INF-γ、IL-17的浓度;脾脏淋巴细胞进行CD4+T细胞分选;RT-...

Alternative Titles

Full title

姜黄素对小鼠实验性自身免疫性脑脊髓炎的自噬调节及抗炎作用

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Author / Creator

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Primary Identifiers

Record Identifier

TN_cdi_wanfang_journals_jfjyxzz201907010

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_jfjyxzz201907010

Other Identifiers

ISSN

0577-7402

DOI

10.11855/j.issn.0577-7402.2019.07.10

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