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新型PET心肌灌注显像剂18F-MyoZone对大鼠心肌细胞的摄取作用及其机制

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新型PET心肌灌注显像剂18F-MyoZone对大鼠心肌细胞的摄取作用及其机制

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_jfjyxzz202005010

新型PET心肌灌注显像剂18F-MyoZone对大鼠心肌细胞的摄取作用及其机制

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Full title

新型PET心肌灌注显像剂18F-MyoZone对大鼠心肌细胞的摄取作用及其机制

Author / Creator

王雅雯 , 赵祚全 , 韩凯 , 张宗耀 and 方纬

Publisher

北京协和医学院中国医学科学院阜外医院核医学科,北京,100037

Journal title

解放军医学杂志, 2020, Vol.45 (5), p.518-525

Language

Chinese

Formats

Articles

Publication information

Publisher

北京协和医学院中国医学科学院阜外医院核医学科,北京,100037

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Contents

R445.5%R445.6; 目的 探讨新型18F标记PET心肌灌注显像剂18F-MyoZone的心肌细胞摄取及滞留机制.方法 ①抑制线粒体呼吸链酶活性机制的研究:使用线粒体呼吸链酶复合体Ⅰ(MC-Ⅰ)活性测定试剂盒测定不同浓度的19F-MyoZone溶液(起始浓度15μmol/L,3倍稀释,稀释12个点)测定19F-MyoZone抑制线粒体呼吸链酶活性的半数抑制率(IC50).②18F-MyoZone与MC-Ⅰ结合的放射自显影研究:采用大鼠心肌组织切片,分别与生理盐水和4种已知MC-Ⅰ抑制剂(4μmol/L鱼藤酮、4μmol/L 19F-Flurpiridaz、4μmol/L 19F-MyoZone及4μmol/L哒螨灵)孵育,再加入18F-MyoZone进行放射自显影研究,检测18F-M...

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Full title

新型PET心肌灌注显像剂18F-MyoZone对大鼠心肌细胞的摄取作用及其机制

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Record Identifier

TN_cdi_wanfang_journals_jfjyxzz202005010

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_jfjyxzz202005010

Other Identifiers

ISSN

0577-7402

DOI

10.11855/j.issn.0577-7402.2020.05.10

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