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卡马西平对癫痫大鼠中脑腹侧被盖区多巴胺能神经元Kv7.4通道的影响

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卡马西平对癫痫大鼠中脑腹侧被盖区多巴胺能神经元Kv7.4通道的影响

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_jfjyxzz202308003

卡马西平对癫痫大鼠中脑腹侧被盖区多巴胺能神经元Kv7.4通道的影响

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Full title

卡马西平对癫痫大鼠中脑腹侧被盖区多巴胺能神经元Kv7.4通道的影响

Author / Creator

王大永 , 裴剑 , 洪铭岩 , 徐翔 , 高云鹤 , 郑宇 , 王凯杰 and 崔建忠

Publisher

唐山市工人医院神经介入科,河北唐山 063000%唐山市工人医院神经外科,河北唐山 063000

Journal title

解放军医学杂志, 2023, Vol.48 (8), p.887-892

Language

Chinese

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Articles

Publication information

Publisher

唐山市工人医院神经介入科,河北唐山 063000%唐山市工人医院神经外科,河北唐山 063000

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Contents

R742.1; 目的 观察卡马西平(CBZ)对癫痫大鼠中脑腹侧被盖区(VTA)多巴胺(DA)能神经元Kv7.4通道的影响.方法 50只雄性Wistar大鼠随机分为5组:对照组、癫痫组和低、中、高浓度CBZ组,每组10只.对照组以外的4组大鼠均用氯化锂-匹罗卡品诱发癫痫构建癫痫大鼠模型;模型构建成功后,低、中、高浓度CBZ组分别通过灌胃给予10、30、50 mg/kg CBZ,对照组和癫痫组灌胃给予等量生理盐水,1次/d,连续7 d.观察各组大鼠行为学表现,通过分光光度法检测VTA丙二醛(MDA)、还原型谷胱甘肽(GSH)含量及超氧化物岐化酶(SOD)活性,免疫荧光及激光共聚焦观察各组大鼠VTA区酪氨酸羟化酶(TH)、Kv7.4蛋白的表达,Western blotting检测TH、Kv7.4的...

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Full title

卡马西平对癫痫大鼠中脑腹侧被盖区多巴胺能神经元Kv7.4通道的影响

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Record Identifier

TN_cdi_wanfang_journals_jfjyxzz202308003

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_jfjyxzz202308003

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ISSN

0577-7402

DOI

10.11855/j.issn.0577-7402.1213.2023.0425

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